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2.5 Effect of phosphorylation -synuclein recovered from Lewy bodies of patients affected with sporadic Parkinsons disease and LBD as well as from glial cytoplasmic inclusion bodies in oligodendrocytes of patients affected with Multiple System Atrophy has been found to be heavily phosphorylated in the 129th serine residue of the C terminal domain (Ghanem et al., 2022)

Dugger and Dickson 2017).The group of neurodegenerative diseases includes a significant number of conditions, and Alzheimer's disease (AD), Parkinson's disease (PD), Multiple Sclerosis (MS), Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA) are the main ones (Checkoway et al

Although DKD has historically been considered a glomerular disease, a growing body of evidence suggests that tubular-interstitial injury may be the first alteration in DKD (18, 21)

Cell (2017) 169(2):36171